these were the things one had to handle while keepin one's aspiration for the divine, and a career in sight,

Recurring neck trouble;

constant fatigue;

worn out eye trouble;

long standing knee trouble;

demand for physical activity amidst these troubles;

call for sacrifices from petty pleasures in life;

sacrifice desire; total detachment ;

Put it simple words all nagging physical pains and pleasures; all the problems from outside; both together;